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CODEX - Exploration

K
Written by Kay Chen

The Exploration tab in CODEX primarily contains plots. All the elements within this tab are responsive to selections made via the sidebar filters and the user element items. All the plots in CODEX are interactive, and hovering the mouse on the plot area leads to the appearance of the "mode bar" on the top right-hand corner of the plot. This bar offers options such as zoom, pan, and plot download. Additionally, hovering over a specific data point provides more information about it.

Time Course by Study

The time course by study plot depicts the treatment effect as observed over time. One study is shown per plot and each line represents a different study arm.

Hovering on the points on the line shows information about the treatment, time, and the effect value of a given study arm.

Control arms have grey plot lines, legend labels, and hover labels. Plots that do not contain control arms will use colors other than grey.

ENDPOINT

The endpoint can be chosen by selecting from the dropdown menu or by typing the endpoint name.

TYPE

The type of plot can be changed to “comparative” to view summary statistics for comparisons to controls.

INFO IN CORNER TITLE

Information in the corner title of the plot can be customized.

PAGE, PANELS, and DECIMAL PLACES

The additional settings detail contains options to select the number of panels to display and to set the number of decimal places to show.

Time Course by Treatment

The time course by treatment plot depicts the treatment effect as observed by treatment. One treatment is shown per plot and each line represents a different study arm. Hovering on the points on the line shows information about the study strata, treatment, time, and the effect value of a given study arm.

ENDPOINT

The endpoint can be chosen by selecting from the dropdown menu or by typing the endpoint name.

TYPE

The type of plot can be changed to “comparative” to view summary statistics for comparisons to controls.

PAGE, PANELS, and DECIMAL PLACES

The additional settings detail contains options to select the number of panels to display and to set the number of decimal places to show.

Network Plot

The network plot shows the extent to which a given drug is represented in the database. The size of the drug node is proportional to the number of arms represented in the database for this treatment. The width of the edge represents the number of arms per treatment combination (two nodes). Checkboxes at the top allow for plotting by drug class and showing labels.

Show Plot by Drug Classes

Show Labels

Forest Plot

The forest plot provides a summarising overview of the treatment effects of all studies together with a 95% confidence interval. Each row represents a different treatment group.

TYPE

Two types of forest plots are available: descriptive and comparative.

Descriptive

Comparative

The measure statistics as seen in the plot are summarised in the following table.

LEFT COLUMN(S) and RIGHT COLUMN(S)

Columns can be added to both the left and right sides of the plot.

PAGES

To change pages, slide the point left or right. The current page is shown on the right, and the total number of pages is displayed on the lower right.

DECIMAL PLACES

Select the decimal places you would like displayed under the Mean column.

ROWS

Select the number of rows to display.

Log Transform X-Axis for Ratios

Log transforming the x-axis for ratios

Reverse Data Order

You can reverse the data order by selecting the box.

Symmetric

Plotting points symmetrically around the treatment effect line.

Funnel Plot

The funnel plot depicts potential publication bias within the database.

A variety of measure types for the observed treatment effect can be selected based on the type of endpoint selected in Table 1.

The default index of precision on the y-axis is the inverse standard error. Information in the hover can be customized.

Endpoint Correlation

The endpoint correlation plot allows a visual comparison between two endpoints. Two types of scatterplots are available: descriptive and comparative. Points can be colored by treatment, treatment class, indication, or study design. A slider for smoothness can be used to adjust the correlation. Additional information is provided when hovering over each point.

Covariate vs Endpoint

As in many of the plots above, the covariate vs. endpoint plot allows for the comparison of two elements directly or respectively of the control treatment. Data points can be grouped by color: by randomized.drug.class, randomized.drug, publication.type, and publication.year.

Time Bar Plot

Time bar plots complement time course plots, making it possible to view response to treatments at a given point in time, grouped by study, treatment and endpoint.

Overview Tables

The overview tables show a summary of the database based on the value selected from the “Summary type” dropdown menu on the left-hand side above the table. The level of detail for the summary can be adjusted via the “Summary columns” dropdown. Several characteristics can be selected at once and easily rearranged to display them in the table in the specified order.

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