In the Preview pane, the links in a document will be outlined by a blue box, as already mentioned. In the case that the link needs to be removed, the Delete option would be used.
There are two ways to delete a link in Publish. Links can also be deleted in CROSSCHECK (see “Delete Links through CROSSCHECK” for more information).
Scroll the mouse over the link until an icon with four arrows appears: and click the link with the arrows. The link box now has a red outline around it.
Navigate to the GlobalSubmit Toolbar, found under Tools for Adobe Acrobat or Extended for Adobe Reader and select the Delete Link icon:
Right-click the link and select Delete from the context menu.
Once the delete link command has been sent, Publish will ask for confirmation. By clicking Yes, the link will be removed from the document, and the blue box will be removed.
Delete Links through CROSSCHECK
During the publishing process, a link to target documents may need to be deleted. For instance, when cloning a submission to a different region, the documents might get automatically deleted if the new region does not allow that kind of document. Case Report Forms could be deleted when cloning a US application to the EU specification, for example.
Since the source documents are still part of the submission, you will get broken links. To delete these links easily, you can perform this task through CROSSCHECK.
To delete links in CROSSCHECK, select the CROSSCHECK tab, then select the source document.
Sort the CROSSCHECK grid by the Quality Issues column in descending order (as indicated by the down arrow in the Quality Issues column header in the previous image) and highlight rows that correspond to broken links.
Click the Remove Link(s) icon: , be sure to save your work.