To remove a file reference, select the file reference and select Remove from the Manage or context menu. A removal confirmation popup will appear.
Removal can be done in bulk by going to the Inventory tab in the Navigation pane, selecting a file reference, and using the Control + A function to select all documents in the section. Press the Delete on the keyboard or select the Manage > Remove menu option.
This will remove all selected references.
Note: Removing content is different than deleting it from the eCTD operator, which is discussed in the “Manage Lifecycle” section.